I looked into the numbers and it’s a wash for people under 45. The risks are greater than often presented, likely because the marketing is targeted at people at heightened risk who really do need to be convinced to take it.
I looked into the numbers and it’s a wash for people under 45.
Link? (Perhaps you didn’t take into account the roughly 5 year lag before the reductions start becoming visible?) My own reading of the meta-analyses is the opposite: that while not studied very much, the cost-benefit is probably even more positive than for older people since the all-cause mortality reduction does not seem to vary by age, the benefits seem to be cumulative/have that lag (so you want to start before the cancer/death risks start going up), younger people have far more DALYs to lose, and the risk of bleeding increase substantially in the 70s and higher. No one seems to show any increase in risk or reduction in effect extrapolating from the ~50yo cutoff in most studies, and at least some people like Rothwell are raising the question of suggesting baby aspirin use for the middle-aged.
My impression was that when looking at subgroups the low risk groups didn’t show any significant risk reduction, and that the higher your risk profile goes the more you reduce risk[1]. So I guess a 5 year lag implies it would be reasonable to start taking it at 40. But an individual has access to better predictors than population wide analysis of age cohorts. The problem is that there is no easy way to judge the balance of risks as you age. Mortality from GI bleeding is low, but not that low[2]. I would hazard a guess that someone who gets regular blood panels and finds themselves leaving the very low risk cluster of parameters (ApoA:ApoB, CRP, high BP) it is probably on net worth it.
I’m not a doctor, but my understanding is that aspirin won’t do anything for a heart attack once it starts—the possible benefits are prophylactic, not curative, and come from low doses over time.
there are better things than aspirin to carry with you.
This post would be much more helpful if you had listed those things. The only thing I’m seeing suggested besides aspirin is nitrates of some form, which appear to be prescription.
This post would be much more helpful if you had listed those things.
I am not a doctor and I don’t want to give medical advice to unknown people over the ’net.
If curiousepic has a medical condition that causes him to have a well-founded fear of a heart attack, he really should ask his doctor—who, among other things, will know what that condition is and can write prescriptions.
No. It is a condescending answer which provides no information. My answer points out that things better than aspirin exist but leaves open the question of what would actually be appropriate for the OP. Essentially, it tells him to explore the matter further.
It is a condescending answer which provides no information.
Why do you think it’s condescending?
My answer points out that things better than aspirin exist
But is that true? As far as I can tell, the other things that are available are recommended to people who cannot take aspirin for whatever reason, and so to call them “better” seems not quite right.
Essentially, it tells him to explore the matter further.
But saying “explore the matter further” in response to someone saying “is X worth it?” seems profoundly unhelpful, especially when you don’t actually say that, compared to saying “explore the matter further by talking to your doctor” or “explore the matter further by looking into miracle drug X.”
I looked into the numbers and it’s a wash for people under 45. The risks are greater than often presented, likely because the marketing is targeted at people at heightened risk who really do need to be convinced to take it.
Link? (Perhaps you didn’t take into account the roughly 5 year lag before the reductions start becoming visible?) My own reading of the meta-analyses is the opposite: that while not studied very much, the cost-benefit is probably even more positive than for older people since the all-cause mortality reduction does not seem to vary by age, the benefits seem to be cumulative/have that lag (so you want to start before the cancer/death risks start going up), younger people have far more DALYs to lose, and the risk of bleeding increase substantially in the 70s and higher. No one seems to show any increase in risk or reduction in effect extrapolating from the ~50yo cutoff in most studies, and at least some people like Rothwell are raising the question of suggesting baby aspirin use for the middle-aged.
My impression was that when looking at subgroups the low risk groups didn’t show any significant risk reduction, and that the higher your risk profile goes the more you reduce risk[1]. So I guess a 5 year lag implies it would be reasonable to start taking it at 40. But an individual has access to better predictors than population wide analysis of age cohorts. The problem is that there is no easy way to judge the balance of risks as you age. Mortality from GI bleeding is low, but not that low[2]. I would hazard a guess that someone who gets regular blood panels and finds themselves leaving the very low risk cluster of parameters (ApoA:ApoB, CRP, high BP) it is probably on net worth it.
http://www.nejm.org/doi/full/10.1056/nejm199704033361401
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309903/ (table 4)
Is it worth it to carry around aspirin to take if you even worry you might be having a heart attack, for people under 45?
carrying a small first aid kit in your day bag is pretty reasonable.
I’m not a doctor, but my understanding is that aspirin won’t do anything for a heart attack once it starts—the possible benefits are prophylactic, not curative, and come from low doses over time.
If you worry about having a heart attack, there are better things than aspirin to carry with you.
This post would be much more helpful if you had listed those things. The only thing I’m seeing suggested besides aspirin is nitrates of some form, which appear to be prescription.
I am not a doctor and I don’t want to give medical advice to unknown people over the ’net.
If curiousepic has a medical condition that causes him to have a well-founded fear of a heart attack, he really should ask his doctor—who, among other things, will know what that condition is and can write prescriptions.
Wouldn’t it be better to say something like “ask your doctor, who can give you answers tailored to your medical history,” then?
No. It is a condescending answer which provides no information. My answer points out that things better than aspirin exist but leaves open the question of what would actually be appropriate for the OP. Essentially, it tells him to explore the matter further.
Why do you think it’s condescending?
But is that true? As far as I can tell, the other things that are available are recommended to people who cannot take aspirin for whatever reason, and so to call them “better” seems not quite right.
But saying “explore the matter further” in response to someone saying “is X worth it?” seems profoundly unhelpful, especially when you don’t actually say that, compared to saying “explore the matter further by talking to your doctor” or “explore the matter further by looking into miracle drug X.”