Also, a side note: IMO until someone freezes and unfreezes a mouse (or a vat grown neural network complete with it’s training) and until that can be done on whole brain level, the cryonics should not be approached like medicine but like tissue sample preparation. The goal is to preserve all the information; all the proteins in the cell membranes need to stay where they are; the proteins stuck to micro-tubules ideally should stay where they are, etc. Picture the children toy: magnetic letters on metal board. The letters should largely stay in place. You can’t have any chemicals that would detach anything critical and let it float around. Solvents are highly suspect.
Even then you can still have a big gotcha if some dynamic process is involved in memory.
Also, a side note: IMO until someone freezes and unfreezes a mouse (or a vat grown neural network complete with it’s training) and until that can be done on whole brain level, the cryonics should not be approached like medicine but like tissue sample preparation. The goal is to preserve all the information; all the proteins in the cell membranes need to stay where they are; the proteins stuck to micro-tubules ideally should stay where they are, etc. Picture the children toy: magnetic letters on metal board. The letters should largely stay in place. You can’t have any chemicals that would detach anything critical and let it float around. Solvents are highly suspect.
Even then you can still have a big gotcha if some dynamic process is involved in memory.