When you remove membrane proteins from the membrane without great care, they tend to either aggregate into amorphous hydrophobic goo which is impossible to measure well, or take on a shape that is not the shape they ordinarily take in this new different context.
When you remove membrane proteins from the membrane without great care, they tend to either aggregate into amorphous hydrophobic goo which is impossible to measure well, or take on a shape that is not the shape they ordinarily take in this new different context.