You need to see if the spike peptide included corresponds to the antibody being tested for—and given how many targets there are, I would be surprised if it did.
Despite holding a far lower prior on efficacy, I’m agreeing with Christian—this evidence shouldn’t be a reason to update anywhere nearly as strongly as you did against effectiveness.
Based on the fact sheet, it sounds like they’re using full S1 and S2, which together constitute basically the entire spike protein. You seem to be imagining that they would use short peptides in the test rather than whole proteins or large subunits; any particular reason why?
Not sure that you’d get reactions from large subunits if they fold differently than the full spike—but my biochemistry/immunology isn’t enough to be sure about how this would work.
The marketing material for the test kit has a long description of steps they took to get the same conformation. It’s still marketing material, so I don’t trust it 100%, but there’s at least a plausible story that it should be the same.
You need to see if the spike peptide included corresponds to the antibody being tested for—and given how many targets there are, I would be surprised if it did.
Despite holding a far lower prior on efficacy, I’m agreeing with Christian—this evidence shouldn’t be a reason to update anywhere nearly as strongly as you did against effectiveness.
Based on the fact sheet, it sounds like they’re using full S1 and S2, which together constitute basically the entire spike protein. You seem to be imagining that they would use short peptides in the test rather than whole proteins or large subunits; any particular reason why?
Not sure that you’d get reactions from large subunits if they fold differently than the full spike—but my biochemistry/immunology isn’t enough to be sure about how this would work.
The marketing material for the test kit has a long description of steps they took to get the same conformation. It’s still marketing material, so I don’t trust it 100%, but there’s at least a plausible story that it should be the same.