The top set of links aren’t working but the study to URTI rates is very interesting.
Firstly for the use of 3 doses a month apart—one dose is the standard for BCG.
I had a BCG at about 7 years old due to contact with a diagnosed TB case. Age 11 I had a positive reaction to the tuberculin skin test (Mantoux) but still got given a second dose, even though I told the school nurse it wasn’t recommended - cocky little sh!t even back then and I’m sure she stamped me twice as punishment… Now thinking good for me!
Also, that there was a strong immune response in elderly subjects who tend to be considered as having a weaker immune system overall.
Testing at 6 months from 1st dose:
There were significant increase of IFN-γ and IL-10 levels in the BCG group compared to the placebo group. There were insignificant increase of IFN-γ and IL-10 levels in the pre- and post-BCG group
Memory B cells are present “for decades” so for those that have received the BCG this effect should apply.
For bladder cancer:
BCG is put right into the bladder through a catheter.
A different mode of action than a standard BCG vaccination, not so much boosting the immune system but drawing attention to the cancer cells in a localised manner.
Regarding the “cytokine storm” seen in severe patients—would previous vaccination make this worse? Musings, no idea what reality will be. But countries with vaccination programs v. those without should provide some interesting data.
Did you come across any information about any specific antibodies have been associated with COVID19?
The top set of links aren’t working but the study to URTI rates is very interesting.
Firstly for the use of 3 doses a month apart—one dose is the standard for BCG.
I had a BCG at about 7 years old due to contact with a diagnosed TB case. Age 11 I had a positive reaction to the tuberculin skin test (Mantoux) but still got given a second dose, even though I told the school nurse it wasn’t recommended - cocky little sh!t even back then and I’m sure she stamped me twice as punishment… Now thinking good for me!
Also, that there was a strong immune response in elderly subjects who tend to be considered as having a weaker immune system overall.
Testing at 6 months from 1st dose:
Memory B cells are present “for decades” so for those that have received the BCG this effect should apply.
For bladder cancer:
A different mode of action than a standard BCG vaccination, not so much boosting the immune system but drawing attention to the cancer cells in a localised manner.
Regarding the “cytokine storm” seen in severe patients—would previous vaccination make this worse? Musings, no idea what reality will be. But countries with vaccination programs v. those without should provide some interesting data.
Did you come across any information about any specific antibodies have been associated with COVID19?