About the methanol theory: if it were true, then substances like Abacavir, which can entirely inhibit methanol metabolism to the point that a man on Abacavir drank a full liter of methanol and suffered no toxicity, should greatly decrease the effect of hangovers. There is nothing to support this as far as I could find. Are there any doctors/HIV patients taking Abacavir here with personal experience?
Hmm! I’m not sure about this. The patient in the linked paper received hemodialysis (which, I think, manually takes the methanol out) before his body could get around to metabolizing it into formaldehyde and formic acid. For someone who doesn’t receive hemodialysis, I think the methanol would still have to be metabolized at some point, even if when that happens is much delayed? In which case the same toxic effects of formaldehyde and formic acid would hit, just much later.
About the methanol theory: if it were true, then substances like Abacavir, which can entirely inhibit methanol metabolism to the point that a man on Abacavir drank a full liter of methanol and suffered no toxicity, should greatly decrease the effect of hangovers. There is nothing to support this as far as I could find. Are there any doctors/HIV patients taking Abacavir here with personal experience?
Hmm! I’m not sure about this. The patient in the linked paper received hemodialysis (which, I think, manually takes the methanol out) before his body could get around to metabolizing it into formaldehyde and formic acid. For someone who doesn’t receive hemodialysis, I think the methanol would still have to be metabolized at some point, even if when that happens is much delayed? In which case the same toxic effects of formaldehyde and formic acid would hit, just much later.