I have a lot of uncertainty here so, let me write a shortform for now. I’m not sure to what extend the following thoughts are true and I’m happy about comments
It seems that the body has two immune defense levels. One is in the mucosal immune system and there’s a second that leads to antibodies in the blood.
As a result vaccines that are injected into the blood don’t help much with asymptomatic infection as asymptomatic infections are mostly in the upper respiratory tract and thus don’t really stop blood-vaccinated individuals from infecting others.
RaDVaC that’s injected into the upper respiratory tract however has a good chance to lead to the mucosal immune system providing building antibodies against the virus.
RaDVaC also has the advantage of allowing us to target mutations from new strains very fast.
5x increased infection rate over Delta means that everyone is likely be infected with Omicron regardles of being vaccinated with our existing vaccines.
Cooking up our own RaDVaC might be the only decent move we have in defense of Omicron.
(while we are at it, someone should really give RaDVaC money to fund their research)
I have a lot of uncertainty here so, let me write a shortform for now. I’m not sure to what extend the following thoughts are true and I’m happy about comments
It seems that the body has two immune defense levels. One is in the mucosal immune system and there’s a second that leads to antibodies in the blood.
SARS-CoV-2 infections usually first are in the upper respiratory tract where the mucosal system provides defense and not in where the immune system that provides antibodies that are active in the blood can fight the infection. https://www.frontiersin.org/articles/10.3389/fimmu.2020.611337/full
As a result vaccines that are injected into the blood don’t help much with asymptomatic infection as asymptomatic infections are mostly in the upper respiratory tract and thus don’t really stop blood-vaccinated individuals from infecting others.
RaDVaC that’s injected into the upper respiratory tract however has a good chance to lead to the mucosal immune system providing building antibodies against the virus.
RaDVaC also has the advantage of allowing us to target mutations from new strains very fast.
5x increased infection rate over Delta means that everyone is likely be infected with Omicron regardles of being vaccinated with our existing vaccines.
Cooking up our own RaDVaC might be the only decent move we have in defense of Omicron.
(while we are at it, someone should really give RaDVaC money to fund their research)