Clickbaitier take: Whole S-Protein Vaccines Are Dangerous (The Solution May Surprise You!)
It gives a good overview of the additional challenges to developing COVID-19 vaccines, such as Th-2 immunopathology (allergy-like immune overreaction, seen for some SARS-1 vaccines). This doesn’t cover the details of clinical trials generally (which are hard enough on their own).
It’s quite readable, but if you want bullet-points, here
This one is technically-oriented, and about typical vaccine-development
...as one might guess, people are Cutting Corners for COVID. Not all of the best-practice guidelines are going to be stringently applied.
*...some of which I heard about via other micpie comments. Go figure.
** 60 days from the nCOV DNA sequence to mRNA vaccines starting clinical trials! mRNA is a relatively flexible/easy-to-modify platform, but new and a bit untested.
micpie’s answer here is good! I don’t have a lot to add to it.
Here are a few related reference-links* and a tiny bit of commentary.
COVID-19 vaccine development landscape as of April 9th (post)
ETA: In the Pipeline blog post providing commentary and description of the vaccines furthest along in the pipeline (Apr 23)
ChristianKI’s LW Q for mRNA vaccine development for COVID-19 in particular (something of a spin-off of the afforelinked thread)
Bit of context: Some of the fastest vaccines to hit human trials were mRNA-based vaccines**, although at this point the field is more balanced.
Good article on additional vaccine development challenges for SARS-2
Clickbaitier take: Whole S-Protein Vaccines Are Dangerous (The Solution May Surprise You!)
It gives a good overview of the additional challenges to developing COVID-19 vaccines, such as Th-2 immunopathology (allergy-like immune overreaction, seen for some SARS-1 vaccines). This doesn’t cover the details of clinical trials generally (which are hard enough on their own).
It’s quite readable, but if you want bullet-points, here
2016 Review paper on the typical vaccine development pipeline
This one is technically-oriented, and about typical vaccine-development
...as one might guess, people are Cutting Corners for COVID. Not all of the best-practice guidelines are going to be stringently applied.
*...some of which I heard about via other micpie comments. Go figure.
** 60 days from the nCOV DNA sequence to mRNA vaccines starting clinical trials! mRNA is a relatively flexible/easy-to-modify platform, but new and a bit untested.