But it’s pretty suspicious if two different causes both increase the risk of every single one of those things—if we had a complete graph with random weights on all the connections, then some factors should push some diseases up, while others should push down. Instead, we see a variety of mutations/interventions (like progerias, calorie restriction, etc) which all push most of these things in the same direction, which pretty strongly suggests that they’re operating through the same pathway.
It’s all about the damage to repair/replacement balance. Birds have higher repair rates, as do NMRs, as do bowhead whales. CR decreases synthesis of proteins that could be damaged while simultaneously (and strangely) upregulating repair. It might be instrumental to look at all the TFs activated by CR.
It’s all about the damage to repair/replacement balance. Birds have higher repair rates, as do NMRs, as do bowhead whales. CR decreases synthesis of proteins that could be damaged while simultaneously (and strangely) upregulating repair. It might be instrumental to look at all the TFs activated by CR.