I’m also skeptical of the effectiveness of many existing pharmaceuticals found through this sort of search. It reeks of p-hacking potential, and I have little doubt that pharma companies are very good at p-hacking.
I think p-hacking is effectively fought with the standard of preregistration and requiring two studies. What’s however not effectively fought is goodharting.
If you have a substance that changes a bunch of things in the body and you find out that one of those things is positive in a very specific case under specific trial conditions you can get the drug approved.
If you have a substance that changes a bunch of things in the body and you find out that one of those things is positive in a very specific case under specific trial conditions you can get the drug approved.
I think p-hacking is effectively fought with the standard of preregistration and requiring two studies. What’s however not effectively fought is goodharting.
If you have a substance that changes a bunch of things in the body and you find out that one of those things is positive in a very specific case under specific trial conditions you can get the drug approved.
Yeah, that sounds right. Good point.