if you’re just indiscriminately shoveling heaps of edits into someone’s genome based on a GWAS with too low a sample size to reveal causal SNPs for the desired trait, you’ll be editing a whole bunch of what are actually tags,
What I said was “What you care about is posterior probability of the causal variant’s effect being above the cost-safety threshold”. If you are ‘indiscriminately shoveling’, then you apparently did it wrong.
a whole bunch of things that are related to independent traits other than intelligence,
Pretty much all SNPs are related to something or other. The question is what is the average effect. Given the known genetic correlations, if you pick the highest posterior probability ones for intelligence, then the average effect will be good.
(And in any case, one should be aiming for maximizing the gain across all traits as an index score.)
and a whole bunch of random irrelevant alleles that made it into your selection by random chance.
If they’re irrelevant, then there’s no problem.
This is a sure-fire way to make a therapy that has no chance of working,
No it’s not. If you’re using common SNPs which already exist, why would it ‘have no chance of working’? If some random SNP had some devastating effect on intelligence, then it would not be ranked high.
What I said was “What you care about is posterior probability of the causal variant’s effect being above the cost-safety threshold”. If you are ‘indiscriminately shoveling’, then you apparently did it wrong.
Pretty much all SNPs are related to something or other. The question is what is the average effect. Given the known genetic correlations, if you pick the highest posterior probability ones for intelligence, then the average effect will be good.
(And in any case, one should be aiming for maximizing the gain across all traits as an index score.)
If they’re irrelevant, then there’s no problem.
No it’s not. If you’re using common SNPs which already exist, why would it ‘have no chance of working’? If some random SNP had some devastating effect on intelligence, then it would not be ranked high.