I will grant you that it is indeed possible that we don’t understand enough about the brain to be confident that we won’t just irreversibly ruin test subjects’ brains with such a therapy, but this is much less likely than the possibility that either nothing will happen or that gains will be had, provided such a therapy is successfully developed in a way that makes it feasible.
The bit about the personality was specifically in response to the idea that you could revert brains to childhood-like plasticity. That’s like an additional layer of complexity and unlike gene therapy we don’t know how to begin doing that, so if you ask me, I don’t think it would actually be a thing anyway in the near future. My guess is: most of your intelligence, even the genetic component, is probably determined by development during the phase of highest plasticity. So if you change the genes later you’ll either get no effect or marginal ones compared to what would happen if you changed them in embryos—that is, if it doesn’t also cause other weird side effects.
Experiments are possible but I doubt they’d be risk-free, or honestly, even approved by an ethical committee at all, as things are now. It’s a high risk for a goal that would probably be deemed in itself ethically questionable. And the study surviving for example a cohort “gone bad” would be really hard in terms of public support and funding.
The bit about the personality was specifically in response to the idea that you could revert brains to childhood-like plasticity. That’s like an additional layer of complexity and unlike gene therapy we don’t know how to begin doing that, so if you ask me, I don’t think it would actually be a thing anyway in the near future. My guess is: most of your intelligence, even the genetic component, is probably determined by development during the phase of highest plasticity. So if you change the genes later you’ll either get no effect or marginal ones compared to what would happen if you changed them in embryos—that is, if it doesn’t also cause other weird side effects.
Experiments are possible but I doubt they’d be risk-free, or honestly, even approved by an ethical committee at all, as things are now. It’s a high risk for a goal that would probably be deemed in itself ethically questionable. And the study surviving for example a cohort “gone bad” would be really hard in terms of public support and funding.