Is there any research on why caffeine seems to affect some people more/differently than others? Anecdotally, I’ve noticed over the years that I get the “jitters” after two cups and have to stop because I can’t stand the feeling, whereas others can drink half a pot and barely notice the effects.
I initially thought that these others had just ‘pushed through the jitters’ and built up a tolerance, but some of them have told me they’ve never experienced the jittery feeling I’m talking about. Or maybe it just didn’t make them as uncomfortable as it makes me?
The answer, as with most questions like ‘why does X seem to work well for some people and not others’ is going to be complex. For example, one of the recent links in my newsletter touches on this topic:
Aside from finding some hits, caffeine consumption has long had meaningful heritability estimates (some are cited in that paper, others can be found in Google Scholar with the obvious query ‘caffeine heritability’). So that seems to be part of it: genetics.
Thanks for the paper (that’s a lot of authors!). The complexity you mention makes it difficult to determine whether substance X (caffeine, alcohol, eggs, etc.) has a net positive or negative for any given person when it comes to health benefits. Coffee has been linked to some positive health effects, but maybe only for those people who don’t get the jitters....that’s the sort of thing that would be cool to know. Until then, I’m just going to listen to my body and minimize consumption.
Is there any research on why caffeine seems to affect some people more/differently than others? Anecdotally, I’ve noticed over the years that I get the “jitters” after two cups and have to stop because I can’t stand the feeling, whereas others can drink half a pot and barely notice the effects.
I initially thought that these others had just ‘pushed through the jitters’ and built up a tolerance, but some of them have told me they’ve never experienced the jittery feeling I’m talking about. Or maybe it just didn’t make them as uncomfortable as it makes me?
The answer, as with most questions like ‘why does X seem to work well for some people and not others’ is going to be complex. For example, one of the recent links in my newsletter touches on this topic:
“Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption”, The Coffee and Caffeine Genetics Consortium et al 2014 (excerpts)
Aside from finding some hits, caffeine consumption has long had meaningful heritability estimates (some are cited in that paper, others can be found in Google Scholar with the obvious query ‘caffeine heritability’). So that seems to be part of it: genetics.
Thanks for the paper (that’s a lot of authors!). The complexity you mention makes it difficult to determine whether substance X (caffeine, alcohol, eggs, etc.) has a net positive or negative for any given person when it comes to health benefits. Coffee has been linked to some positive health effects, but maybe only for those people who don’t get the jitters....that’s the sort of thing that would be cool to know. Until then, I’m just going to listen to my body and minimize consumption.