This should be true for any trait that is highly polygenic and that we know many associated variants for, yeah.
I’m not sure how likely this is to practically come up though.
IDK, but if I had to make a guess I would guess that it’s quite rare but does occur. Another sort of example might be: say there’s a couple whose child will likely get some disease D. Maybe the couple has a very high genetic predisposition for D that can’t be attenuated enough using GE, or maybe it’s a non-genetic disease that’s transmissible. And say there’s a rare variant that protects against D (which neither parent has). It would be a risk, and potentially a consent issue, to experiment with editing in the rare variant; but it might be good all things considered. (If this sounds like sci-fi, consider that this is IIUC exactly the scenario that happened with the first CRISPR-edited baby! In that case there were multiple methodological issues, and the edit itself might have been a bad idea even prospectively, but the background scenario was like that.)
This should be true for any trait that is highly polygenic and that we know many associated variants for, yeah.
IDK, but if I had to make a guess I would guess that it’s quite rare but does occur. Another sort of example might be: say there’s a couple whose child will likely get some disease D. Maybe the couple has a very high genetic predisposition for D that can’t be attenuated enough using GE, or maybe it’s a non-genetic disease that’s transmissible. And say there’s a rare variant that protects against D (which neither parent has). It would be a risk, and potentially a consent issue, to experiment with editing in the rare variant; but it might be good all things considered. (If this sounds like sci-fi, consider that this is IIUC exactly the scenario that happened with the first CRISPR-edited baby! In that case there were multiple methodological issues, and the edit itself might have been a bad idea even prospectively, but the background scenario was like that.)