Links: Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice (press release)(paper)
I think the radial arm water maze experiment’s results are particularly interesting; it measures learning and memory (see fig 2c which is visible even with the paywall). There’s a day one and day two of training and the old mice (18 months) improve somewhat during the first day and then more or less start over on the second day in terms of the errors they are making. This is also true if the old mice are treated with 8 injections of old blood over the course of 3 weeks (the new curves lie pretty much on top of the old curves in supplemental figure 7d). Young mice (3 months) perform better than the old mice (supplemental figure 5d) they learn faster on the first day and retain it when the second day starts (supp 7d).
However, if you give 8 injections of 100 micro liters of blood from 3 month old mice to 18 month old mice, the treated mice perform dramatically better than the old-blood treated old mice (2c) and much more like young mice (this comparison is less certain; I’m comparing one line from 2c to one line from supp. 7d, but that’s how it looks by eye).
Links: Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice (press release)(paper)
I think the radial arm water maze experiment’s results are particularly interesting; it measures learning and memory (see fig 2c which is visible even with the paywall). There’s a day one and day two of training and the old mice (18 months) improve somewhat during the first day and then more or less start over on the second day in terms of the errors they are making. This is also true if the old mice are treated with 8 injections of old blood over the course of 3 weeks (the new curves lie pretty much on top of the old curves in supplemental figure 7d). Young mice (3 months) perform better than the old mice (supplemental figure 5d) they learn faster on the first day and retain it when the second day starts (supp 7d).
However, if you give 8 injections of 100 micro liters of blood from 3 month old mice to 18 month old mice, the treated mice perform dramatically better than the old-blood treated old mice (2c) and much more like young mice (this comparison is less certain; I’m comparing one line from 2c to one line from supp. 7d, but that’s how it looks by eye).
One factor in the new blood that plays a role is GDF11. From another paper: “we show that GDF11 alone can improve the cerebral vasculature and enhance neurogenesis”
The New York Times gives an overview and other known effects of young blood such as rejuvenating the musculature / heart / vasculature of old mice with young blood. Young Blood May Hold Key to Reversing Aging, e.g. Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle