Here is an example of something that comes close from “The Selfish Gene”:
One of the best-known segregation distorters is the so-called t gene in mice. When a mouse has two t genes it either dies young or is sterile, t is therefore said to be lethal in the homozygous state. If a male mouse has only one t gene it will be a normal, healthy mouse except in one remarkable respect. If you examine such a male’s sperms you will find that up to 95 per cent of them contain the t gene, only 5 per cent the normal allele. This is obviously a gross distortion of the 50 per cent ratio that we expect. Whenever, in a wild population, a t allele happens to arise by mutation, it immediately spreads like a brushfire. How could it not, when it has such a huge unfair advantage in the meiotic lottery? It spreads so fast that, pretty soon, large numbers of individuals in the population inherit the t gene in double dose (that is, from both their parents). These individuals die or are sterile, and before long the whole local population is likely to be driven extinct. There is some evidence that wild populations of mice have, in the past, gone extinct through epidemics of t genes.
Not all segregation distorters have such destructive side-effects as t. Nevertheless, most of them have at least some adverse consequences.
From the discussion of human-engineered gene drives, they would only cause sterility in one sex, which would help avoid the gene dying off as quickly.
Here is an example of something that comes close from “The Selfish Gene”:
From the discussion of human-engineered gene drives, they would only cause sterility in one sex, which would help avoid the gene dying off as quickly.