For the most part, all those labels are just labels for where on the tree of all sequences it falls. There is almost no evidence of widespread functional mutants. They’re useful for tracking the spread of the virus around the globe.
There is one mutation in the S protein at the root of the European strains that you could *imagine* having an effect on the function of the fusion protein but there is no particularly strong evidence that it’s doing much—a little equivocal difference in the measured PCR cycles required for detection from samples, but that could have to do with the fact that they happened at different times when people were getting tested at different disease stages or on different equipment. It is more common more recently relative to the other lineages in Europe and America, but that could very easily just be because it is the only lineage in Italy and once Italy exploded its shrapnel founded a lot of new transmission chains all over Europe and America. It could very easily just be a bottleneck effect having to do with breaking into a new area.
Much more interesting are a few small lineages that have actually lost whole accessory proteins involved in suppressing the innate immune response, but that’s a total of like 7 patients found to have them.
For the most part, all those labels are just labels for where on the tree of all sequences it falls. There is almost no evidence of widespread functional mutants. They’re useful for tracking the spread of the virus around the globe.
There is one mutation in the S protein at the root of the European strains that you could *imagine* having an effect on the function of the fusion protein but there is no particularly strong evidence that it’s doing much—a little equivocal difference in the measured PCR cycles required for detection from samples, but that could have to do with the fact that they happened at different times when people were getting tested at different disease stages or on different equipment. It is more common more recently relative to the other lineages in Europe and America, but that could very easily just be because it is the only lineage in Italy and once Italy exploded its shrapnel founded a lot of new transmission chains all over Europe and America. It could very easily just be a bottleneck effect having to do with breaking into a new area.
Much more interesting are a few small lineages that have actually lost whole accessory proteins involved in suppressing the innate immune response, but that’s a total of like 7 patients found to have them.