Will Arenamontanus or someone else please elaborate on the problem with amphetamines not shared with modafinil? To tell me that amphetamines “impair considered choice” is not enough to inform a session with a search engine. I am aware that amphetamines can impair certain kinds of judgement, but was told that that happens only at doses high enough to cause euphoria. Thanks.
The quick answer is that most stimulants make animals and people use well-learned stimulus-response responses more than considering the situation and figuring out an appropriate response, and often makes them impulsive—when it partially looks like a situation when you should do “A”, the A response is hard to resist. A classic case was the US airforce friendly fire incident blamed on dexamphetamine. This is where the improved response inhibition of modafinil comes in. See
Turner DC, Clark L, Dowson J, Robbins TW, Sahakian BJ. Modafinil improves cognition and response inhibition in adult attention-deficit/hyperactivity disorder. Biol Psychiatry. 2004 May 15;55(10):1031-40.
Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ. Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology (Berl). 2003 Jan;165(3):260-9. Epub 2002 Nov 1.
Will Arenamontanus or someone else please elaborate on the problem with amphetamines not shared with modafinil? To tell me that amphetamines “impair considered choice” is not enough to inform a session with a search engine. I am aware that amphetamines can impair certain kinds of judgement, but was told that that happens only at doses high enough to cause euphoria. Thanks.
The quick answer is that most stimulants make animals and people use well-learned stimulus-response responses more than considering the situation and figuring out an appropriate response, and often makes them impulsive—when it partially looks like a situation when you should do “A”, the A response is hard to resist. A classic case was the US airforce friendly fire incident blamed on dexamphetamine. This is where the improved response inhibition of modafinil comes in. See
Turner DC, Clark L, Dowson J, Robbins TW, Sahakian BJ. Modafinil improves cognition and response inhibition in adult attention-deficit/hyperactivity disorder. Biol Psychiatry. 2004 May 15;55(10):1031-40.
Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ. Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology (Berl). 2003 Jan;165(3):260-9. Epub 2002 Nov 1.