I think until recent throughput issues PCR was basically good enough and some scientists were attached to their hard learned PCR skills, LAMP was new and scary and unfamiliar enough that lots of scientists just didn’t know it was easier and better. Primer design was a serious obstacle in the early days of LAMP but is easy with modern computer primer design tools.
LAMP is also only better than PCR for the things that it is better at. PCR has general applications to biological science and LAMP is only good for an important subset of possible PCR diagnostic tests. I think mainstream scientists lack the understanding of what LAMP can and can’t do and for something as sensitive as HIV testing I can understand that people don’t want to rock the boat and switch to LAMP from PCR.
It’s also relevant that LAMP is only recently leaving patent protection. I’m not sure what the licensing cost structure used to be but now there are no patent license fees pushing through adoption is simpler:
I am going to try and scale towards selling RT-LAMP kits to US states in very high unit amounts; I’m feeling optimistic.
I think until recent throughput issues PCR was basically good enough and some scientists were attached to their hard learned PCR skills, LAMP was new and scary and unfamiliar enough that lots of scientists just didn’t know it was easier and better. Primer design was a serious obstacle in the early days of LAMP but is easy with modern computer primer design tools.
LAMP is also only better than PCR for the things that it is better at. PCR has general applications to biological science and LAMP is only good for an important subset of possible PCR diagnostic tests. I think mainstream scientists lack the understanding of what LAMP can and can’t do and for something as sensitive as HIV testing I can understand that people don’t want to rock the boat and switch to LAMP from PCR.
It’s also relevant that LAMP is only recently leaving patent protection. I’m not sure what the licensing cost structure used to be but now there are no patent license fees pushing through adoption is simpler:
I am going to try and scale towards selling RT-LAMP kits to US states in very high unit amounts; I’m feeling optimistic.