For the purposes of this discussion I’ll define it as a civilization sufficiently advanced to be become global. The relevant point is that no local calamity will extinguish it,
The problem is that the global nature of civilization can also cause calamities to become global.
The Roman Empire was more global than its predecessors but was still fallen mainly by internally generated calamities.
One generation passeth away, and another generation cometh: but the earth abideth for ever.
The sun also ariseth, and the sun goeth down, and hasteth to his place where he arose.
The wind goeth toward the south, and turneth about unto the north; it whirleth about continually, and the wind returneth again according to his circuits.
All the rivers run into the sea; yet the sea is not full; unto the place from whence the rivers come, thither they return again.
All things are full of labour; man cannot utter it: the eye is not satisfied with seeing, nor the ear filled with hearing.
The thing that hath been, it is that which shall be; and that which is done is that which shall be done: and there is no new thing under the sun.
The problem is that the global nature of civilization can also cause calamities to become global.
The Roman Empire was more global than its predecessors but was still fallen mainly by internally generated calamities.
Life is not static. All empires fall eventually.