Regarding the link: Possibly you did not activate the markdown editor for your profile? In that case you can create one by marking the link-text: a hover-menu will appear with the option to add a link
The link is working for me, though the markdown you used isn’t formatting the way it is supposed to.
So if I understand correctly, Moderna gave a third dose of either the B.1.351 variant shot or the original 1273 shot to patients and found that those given the B.1.351 shot had higher levels of neutralizing antibodies against the variant?
This seems to suggest that we could do strain specific boosters against COVID. I suspect that would be particularly true for Omicron since it has so much more antigenic drift than the other variants.
An alternate interpretation of the result is that Beta just didn’t have much immune escape. That fact that it was crushed by Delta suggests that. The vaccine produced antibodies that were more tuned to Beta than those from the original vaccine, but the difference was slight, just a factor of 2. We won’t know about OAS until we have a variant with real immune escape, which may well be Omicron. But I’m not worried about OAS because it’s a lower order effect.
There’s this post, which suggests that Original antigenic sin is unlikely to be a problem. I really hope that’s true.
Regarding the link: Possibly you did not activate the markdown editor for your profile?
In that case you can create one by marking the link-text: a hover-menu will appear with the option to add a link
Thank you, I had no idea markdown needed to be actively activated in the profile.
The link is working for me, though the markdown you used isn’t formatting the way it is supposed to.
So if I understand correctly, Moderna gave a third dose of either the B.1.351 variant shot or the original 1273 shot to patients and found that those given the B.1.351 shot had higher levels of neutralizing antibodies against the variant?
This seems to suggest that we could do strain specific boosters against COVID. I suspect that would be particularly true for Omicron since it has so much more antigenic drift than the other variants.
An alternate interpretation of the result is that Beta just didn’t have much immune escape. That fact that it was crushed by Delta suggests that. The vaccine produced antibodies that were more tuned to Beta than those from the original vaccine, but the difference was slight, just a factor of 2. We won’t know about OAS until we have a variant with real immune escape, which may well be Omicron. But I’m not worried about OAS because it’s a lower order effect.