Appendix A: Definitions for Israel Nationwide Pfizer Study
Variable
Definition
Outcomes
Documented SARSCoV-2 Infection
A PCR confirmed infection.
Asymptomatic SARSCoV-2 Infection 0
A PCR-confirmed infection with no report of symptoms during referral and during initial physician questioning.
COVID-19 (symptomatic SARSCoV-2 Infection)
A PCR-confirmed infection with report of symptoms during the PCR referral / during the followup in the community setting / COVID-19 related hospitalization / COVID-19 related death. Existing symptoms were considered when the physician or nurse checked the “symptomatic” option in the EMR, or when the following specific symptoms were recorded: fever or chills, cough, shortness of breath or difficulty breathing, sore throat, headache, weakness, congestion or runny nose, myalgia, nausea or vomiting, diarrhea, abdominal pain, loss of taste or smell, inability to eat or drink.
COVID-19 related hospitalization
A hospitalization that was reported to the Israeli MOH as a hospitalization of a SARS-CoV-2 infected individual.
COVID-19 related severe state
As defined by the hospitalizing institution per the Israeli MOH guidelines, consistent with the NIH criteria for severe illness or critical illness:
Individuals who have SpO2 <94% on room air at sea level, a ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2) <300 mm Hg, respiratory frequency >30 breaths/min, or lung infiltrates >50%.
Critical Illness: Individuals who have respiratory failure, septic shock, and/or multiple organ dysfunction.
COVID-19 related death
A death of a SARS-CoV-2 infected individual reported to the Israeli MOH.
Vaccination Periods
Days 14-20
From the 14 days until 20 days after the first dose
Days 21-27
From 21 days and until 27 days after the first dose
Days 0-6 after the 2nd dose
From the 2nd dose and until 6 days later
Days 7+ after the 2nd dose
From day 7 after the 2nd dose and until the end of the follow-up
Appendix A: Definitions for Israel Nationwide Pfizer Study
As defined by the hospitalizing institution per the Israeli MOH guidelines, consistent with the NIH criteria for severe illness or critical illness:
Individuals who have SpO2 <94% on room air at sea level, a ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2) <300 mm Hg, respiratory frequency >30 breaths/min, or lung infiltrates >50%.
Critical Illness: Individuals who have respiratory failure, septic shock, and/or multiple organ dysfunction.