There was also a paper late 2015 that showed that the apicomplexans (toxo,malaria, chagas) were using the myelin sheath to get access to the brain and other major nerve bundles. There was another one that showed maltose or lactose could open the blood/brain barrier for up to 20 min., and there is some evidence that the plaques are actually to isolate and reduce the interference of the api spores that had burrowed into the nerve sheaths on the brain surfaces.
the recent paper published by Maria Fiorentino and colleagues\
“After that little rant, the paper from Fiorentino is an interesting one in that the goal was to “investigate whether an altered BBB and gut permeability is part of the pathophysiology of ASD.” To do this, tissue from both brain and gastrointestinal (GI) tract donated by a small number of deceased and non-deceased participants who were diagnosed with autism, schizophrenia or nothing related (not-autism controls) were analysed “for gene and protein expression profiles.” This work was undertaken on the basis of “the interconnectivity of the gut–brain axis, [that] suggests that inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of antigens or activated immune complexes through a permissive blood–brain barrier (BBB), can be part of the chain of events leading to neuroinflammation and thereby subsequent disease.” I might add that the use of the word ‘disease’ in that sentence is, I think, aiming to describe the physiological effects of ‘leaky barriers’ not the diagnosis of autism.”
There was also a paper late 2015 that showed that the apicomplexans (toxo,malaria, chagas) were using the myelin sheath to get access to the brain and other major nerve bundles. There was another one that showed maltose or lactose could open the blood/brain barrier for up to 20 min., and there is some evidence that the plaques are actually to isolate and reduce the interference of the api spores that had burrowed into the nerve sheaths on the brain surfaces.
And more on the BBB and the gut barrier.
the recent paper published by Maria Fiorentino and colleagues\
“After that little rant, the paper from Fiorentino is an interesting one in that the goal was to “investigate whether an altered BBB and gut permeability is part of the pathophysiology of ASD.” To do this, tissue from both brain and gastrointestinal (GI) tract donated by a small number of deceased and non-deceased participants who were diagnosed with autism, schizophrenia or nothing related (not-autism controls) were analysed “for gene and protein expression profiles.” This work was undertaken on the basis of “the interconnectivity of the gut–brain axis, [that] suggests that inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of antigens or activated immune complexes through a permissive blood–brain barrier (BBB), can be part of the chain of events leading to neuroinflammation and thereby subsequent disease.” I might add that the use of the word ‘disease’ in that sentence is, I think, aiming to describe the physiological effects of ‘leaky barriers’ not the diagnosis of autism.”