We have to ask why smallpox was a unique event, and we never used this method for any other virus. Did we even ever consider it?
If you can give someone immunity by giving them a small smallpox infection the logical next step is to give them dead smallpox virus that’s enough to get an immune reaction to produce immunity but that in most cases won’t produce infection. That’s the crudest form to do vaccination.
I see no reason why you would want to give a patient living smallpox virus over giving them dead smallpox virus if you have a decent amount of resources. The same goes for other viruses.
Policy-wise it might make more sense in third-world countries where you have neither the resources to self-quarenteen people nor to give everybody dea smallpox virus as a vaccine.
If you can give someone immunity by giving them a small smallpox infection the logical next step is to give them dead smallpox virus that’s enough to get an immune reaction to produce immunity but that in most cases won’t produce infection. That’s the crudest form to do vaccination.
I see no reason why you would want to give a patient living smallpox virus over giving them dead smallpox virus if you have a decent amount of resources. The same goes for other viruses.
Policy-wise it might make more sense in third-world countries where you have neither the resources to self-quarenteen people nor to give everybody dea smallpox virus as a vaccine.