The specific silliness of “humans before business” is pretty straightforward: business is something humans do, and “humans before this thing that humans do” is meaningless or tautological. Business doesn’t exist without humans, right?
Eh, it’s not as absurd as that. You know how we worry that AI’s might optimize something easily quantifiable, but in a way that destroys human value? I think it’s entierly reasonable to think that businesses may do the same thing, and optimize for their own profit in a way that destroys human value in general. For example, the way Facebook is to a significant extent designed to maximize getting clicks and eyeballs in manipulative ways that do not actually serve human communication needs for the users.
If you’re in a simulation, the only reference class that matters is “how long has the simulation been running for”. And most likely, for anyone running billions of simulations, the large majority of them are short, only a few minutes or hours. Maybe you could run a simulation that lasts as long as the universe does in subjective time, but most likely there would be far more short simulations.
Basically, I don’t think you can use the doomsday argument at all if you’re in a simulation, unless you know how long the simulation’s been running, which you can’t know. You can accept either SA or DA, but you can’t use both of them at the same time.