Thank you for your thoughts on this. My understanding is that proteins sometimes take different shapes inside the body compared to outside, where crystallography measurements are. For these cases, would you say it is true that Alphafold is able to predict in vitro protein structures, but not necessarily in vivo protein structures (esp. considering that the models don’t take into account ab initio processes directly)?
Thank you for your thoughts on this. My understanding is that proteins sometimes take different shapes inside the body compared to outside, where crystallography measurements are. For these cases, would you say it is true that Alphafold is able to predict in vitro protein structures, but not necessarily in vivo protein structures (esp. considering that the models don’t take into account ab initio processes directly)?