I encountered this while I was reading about an obscure estradiol ester, Estradiol undecylate, used for hormone replacement therapy and treating prostate cancer. It’s very useful because it has a super long half-life, but it was discontinued. I had to reread the article to be sure I understood that the standard dose chosen arbitrarily in the first trials was hundreds of times larger than necessary, leading to massive estrogen overdoses and severe side effects that killed many people due to cardiovascular complications, and yet these insane doses were typical for decades and might’ve caused its discontinuation.
I encountered this while I was reading about an obscure estradiol ester, Estradiol undecylate, used for hormone replacement therapy and treating prostate cancer. It’s very useful because it has a super long half-life, but it was discontinued. I had to reread the article to be sure I understood that the standard dose chosen arbitrarily in the first trials was hundreds of times larger than necessary, leading to massive estrogen overdoses and severe side effects that killed many people due to cardiovascular complications, and yet these insane doses were typical for decades and might’ve caused its discontinuation.