Right, Wikipedia cites a 1972 paper using viruses to deliver DNA, but no vaccine until 1984. Whereas, mRNA in lipids went from delivery in 1989 to a vaccine in 1993-1994. So twenty years on one metric, but ten years on another metric that probably screens off the first one by virtue of coming later.
But that’s just playing around. Obstacles artificially created by the FDA are real obstacles. To the extent that the vaccine-hesitant mean anything by “old-fashioned,” they mean large scale experience in humans. More people received vector vaccines in the Oxford trials than in all deployment before. If you want to know about Bell’s palsy, that’s the only way to find out. On the other hand, if you want years of follow-up, a 2015 trial of vector vaccines could have been an big advantage over mRNA vaccines, although I don’t know if they actually followed up after years. With no placebo group, it’s not clear what analysis they could make.
Right, Wikipedia cites a 1972 paper using viruses to deliver DNA, but no vaccine until 1984. Whereas, mRNA in lipids went from delivery in 1989 to a vaccine in 1993-1994. So twenty years on one metric, but ten years on another metric that probably screens off the first one by virtue of coming later.
But that’s just playing around. Obstacles artificially created by the FDA are real obstacles. To the extent that the vaccine-hesitant mean anything by “old-fashioned,” they mean large scale experience in humans. More people received vector vaccines in the Oxford trials than in all deployment before. If you want to know about Bell’s palsy, that’s the only way to find out. On the other hand, if you want years of follow-up, a 2015 trial of vector vaccines could have been an big advantage over mRNA vaccines, although I don’t know if they actually followed up after years. With no placebo group, it’s not clear what analysis they could make.