“But something has really become clear: The mixing really is most impactful when you have a DNA/adenovirus vaccine first followed by the mRNA vaccine,” Gandhi said. WaPo
This is definitely true in terms of antibody fold induction: JnJ followed by either Pfizer or Moderna have the highest fold induction ratios.
However, they’re starting from a lower baseline, since JnJ doesn’t induce such high ab levels to begin with. (Though it might be better at training T cells and memory B cells, and have longer persistence? It’s kind of frustratingly complicated, to me.)
If you look at absolute ab levels, JnJ followed by Moderna looks best.
(Data source: FDA presentation by Lyke, cited in previous comment, slide 22.)
This is definitely true in terms of antibody fold induction: JnJ followed by either Pfizer or Moderna have the highest fold induction ratios.
However, they’re starting from a lower baseline, since JnJ doesn’t induce such high ab levels to begin with. (Though it might be better at training T cells and memory B cells, and have longer persistence? It’s kind of frustratingly complicated, to me.)
If you look at absolute ab levels, JnJ followed by Moderna looks best.
(Data source: FDA presentation by Lyke, cited in previous comment, slide 22.)