OK. I’ll accept your rephrasing. Let us assume that “calories out” is always difficult to estimate and depends on a lot of factors such as muscle mass and total calorie intake.
I took the original comment to mean that we can eat very large amounts of fat and protein, because our bodies would somehow react, in response to the proportion of different nutrients in our diet, and change how efficiently we use energy. I find it difficult to believe that this would explain much of change in body weight. I find it much easier to believe that it would change our appetites and thus reduce calorie intake.
I am certainly willing to update my priors if someone convinces me of a plausible mechanism by which proportion of each nutrient alters efficiency of energy use..
OK. I’ll accept your rephrasing. Let us assume that “calories out” is always difficult to estimate and depends on a lot of factors such as muscle mass and total calorie intake.
I took the original comment to mean that we can eat very large amounts of fat and protein, because our bodies would somehow react, in response to the proportion of different nutrients in our diet, and change how efficiently we use energy. I find it difficult to believe that this would explain much of change in body weight. I find it much easier to believe that it would change our appetites and thus reduce calorie intake.
I am certainly willing to update my priors if someone convinces me of a plausible mechanism by which proportion of each nutrient alters efficiency of energy use..