For example, quantum computing/reversible computing or superconductors would entirely break his statement about optimal nanobots.
Reversible/Quantum computing is not as general as irreversible computing. Those paradigms only accelerate specific types of computations, and they don’t help at all with bit erasing/copying. The core function of a biological cell is to replicate, which requires copying/erasing bits, which reversible/quantum computing simply don’t help with at all, and in fact just add enormous extra complexity.
Reversible/Quantum computing is not as general as irreversible computing. Those paradigms only accelerate specific types of computations, and they don’t help at all with bit erasing/copying. The core function of a biological cell is to replicate, which requires copying/erasing bits, which reversible/quantum computing simply don’t help with at all, and in fact just add enormous extra complexity.