“Chemical cisgenderization” is usually just called “detransition.” To do it, you stop taking hormones. Unless you’ve had the appropriate surgeries (which most of us haven’t because it’s very expensive) your body will do it by itself.
Transfeminine HRT consists of synthetic estrogen and an anti-androgen of some sort (usually spironolactone or finasteride.) Estrogen monotherapy, in higher doses, is coming more into vogue now that more has been published that suggests it’s more effective.
Anyway, I know some people who have tried. I’m told the dysphoria comes right back, worse than ever. I know at least one (AMAB nonbinary) person who actually needed to take low-dose T after their orchiectomy, although the dose was an order of magnitude less than what their body naturally produced, but that’s rather an exceptional case.
Actual desistance rates are on the order of a few percent*, and >90% of those are for reasons other than “I’m not actually trans.” [0]
“Chemical cisgenderization” is usually just called “detransition.” To do it, you stop taking hormones. Unless you’ve had the appropriate surgeries (which most of us haven’t because it’s very expensive) your body will do it by itself.
Transfeminine HRT consists of synthetic estrogen and an anti-androgen of some sort (usually spironolactone or finasteride.) Estrogen monotherapy, in higher doses, is coming more into vogue now that more has been published that suggests it’s more effective.
Anyway, I know some people who have tried. I’m told the dysphoria comes right back, worse than ever. I know at least one (AMAB nonbinary) person who actually needed to take low-dose T after their orchiectomy, although the dose was an order of magnitude less than what their body naturally produced, but that’s rather an exceptional case.
Actual desistance rates are on the order of a few percent*, and >90% of those are for reasons other than “I’m not actually trans.” [0]
[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213007/