As for why blood clots are a problem in the first place… one of the hypotheses I’ve seen floating around is that it might be tied into complement system malfunction?
Warning that this is pretty speculative...
The complement system is an immune response that uses C-protein complexes to poke holes in membranes to kill cells and fight large infections.
This paper used results from 5 lung autopsies and tried to draw a link between the prolonged procoagulant state in the lungs with excessive activity of the complement system. I could barely follow it beyond that.
I had also heard before that complement system malfunctions were thought to be connected to bad vaccine response for SARS-1.
I don’t feel certainty in this at all. But it comes up semi-consistently, and I don’t have a better theory yet.
I think it’s a horse, not a zebra. ACE2 is expressed on endothelial cells lining blood vessels. If you get bad viremia the inner sheath of blood vessels, especially in heavily infected organs, probably just gets all messed up.
As for why blood clots are a problem in the first place… one of the hypotheses I’ve seen floating around is that it might be tied into complement system malfunction?
Warning that this is pretty speculative...
The complement system is an immune response that uses C-protein complexes to poke holes in membranes to kill cells and fight large infections.
This paper used results from 5 lung autopsies and tried to draw a link between the prolonged procoagulant state in the lungs with excessive activity of the complement system. I could barely follow it beyond that.
I had also heard before that complement system malfunctions were thought to be connected to bad vaccine response for SARS-1.
I don’t feel certainty in this at all. But it comes up semi-consistently, and I don’t have a better theory yet.
I think it’s a horse, not a zebra. ACE2 is expressed on endothelial cells lining blood vessels. If you get bad viremia the inner sheath of blood vessels, especially in heavily infected organs, probably just gets all messed up.