I would be very surprised if inflammation or loss of proteostasis did not have any effect on fascia, if only because they have negative effect on ~everything. But more importantly, I don’t think there’s any significant number of people dying from fascia stiffness? That’s one of the main ideas behind the hallmarks of aging, that you don’t have to solve the entire problem in its every minuscule aspect at once. If you could just forestall all these hallmarks or even just some of them, you could probably increase lifespan and healthspan significantly, thus buying more time to fix other problems (or develop completely knew approaches like mind uploading or regenerative medicine or whatever else).
I would be very surprised if inflammation or loss of proteostasis did not have any effect on fascia, if only because they have negative effect on ~everything. But more importantly, I don’t think there’s any significant number of people dying from fascia stiffness? That’s one of the main ideas behind the hallmarks of aging, that you don’t have to solve the entire problem in its every minuscule aspect at once. If you could just forestall all these hallmarks or even just some of them, you could probably increase lifespan and healthspan significantly, thus buying more time to fix other problems (or develop completely knew approaches like mind uploading or regenerative medicine or whatever else).