Second, there are viruses that evolved to coexist with immune system and maintain stable populations inside human host without provoking super-exponential immune response. New variants of corona viruses that gain this ability will become permanent residents in people who are partially immune. Eventually these variants will constitute a majority of corona virus populations in human hosts.
Nice discovery! I will look into it. In my naive understanding, I imagine that each strain only infects a small fraction of all cells, so that two strains should rarely infect the same cell. On the other hand, the abstract explicitly mentions competition between strains, suggesting that there must be connection to multiple infection of cells.
First, there should be competition between different virus variants for the cells to infect. This paper
( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426218/) discusses competitive exclusion for shorter infection cascades.
Second, there are viruses that evolved to coexist with immune system and maintain stable populations inside human host without provoking super-exponential immune response. New variants of corona viruses that gain this ability will become permanent residents in people who are partially immune. Eventually these variants will constitute a majority of corona virus populations in human hosts.
This reminds me—have you read about some of the connections between covid outcomes and cytomegalovirus? It’s pretty fascinating.
Nice discovery! I will look into it.
In my naive understanding, I imagine that each strain only infects a small fraction of all cells, so that two strains should rarely infect the same cell. On the other hand, the abstract explicitly mentions competition between strains, suggesting that there must be connection to multiple infection of cells.