Senescent-cell-based therapeutics feels like somewhat of a dead-end...senescence happens for a reason, and clearing out these cells have some second-order downsides. E.g., the inflammation caused by senescence is important for acute injury repair. I am less well-read on this area though!
Metformin and rapamicyn are promising in the same way ozempic is promising; helping curtail metabolic problems helps a LOT of things, but it won’t lead to dramatic changes in lifespan. Definitely in healthspan! But even there, nothing insane.
Imo, partial cellular reprogramming is the only real viable approach we have left, I’m kinda unsure what else the field has to offer if that ends up failing.
Thank you for reading!
Senescent-cell-based therapeutics feels like somewhat of a dead-end...senescence happens for a reason, and clearing out these cells have some second-order downsides. E.g., the inflammation caused by senescence is important for acute injury repair. I am less well-read on this area though!
Metformin and rapamicyn are promising in the same way ozempic is promising; helping curtail metabolic problems helps a LOT of things, but it won’t lead to dramatic changes in lifespan. Definitely in healthspan! But even there, nothing insane.
Imo, partial cellular reprogramming is the only real viable approach we have left, I’m kinda unsure what else the field has to offer if that ends up failing.