One thought: One could probably do mice studies where instead of maximizing a polygenic score, non-consensus variants are edited to reduce mutational load. If that had positive effects it would be a huge result.
That’s a decent idea. I had thought to do it with cows or some livestock animal for which we do have decent polygenic predictors, but mice are of course the obvious first step for animal trials.
One thought: One could probably do mice studies where instead of maximizing a polygenic score, non-consensus variants are edited to reduce mutational load. If that had positive effects it would be a huge result.
That’s a decent idea. I had thought to do it with cows or some livestock animal for which we do have decent polygenic predictors, but mice are of course the obvious first step for animal trials.