In the post you talked about editing all 237 loci to make diabetes negligible, but now you talk about the normal human range. I think that is more correct. Editing all 237 loci would leave the normal human range; the effect on diabetes would be unpredictable and the probability of bad effects likely. Not because of pleiotropy, but just the breakdown of a control system outside of its tested regime.
In the post you talked about editing all 237 loci to make diabetes negligible, but now you talk about the normal human range. I think that is more correct. Editing all 237 loci would leave the normal human range; the effect on diabetes would be unpredictable and the probability of bad effects likely. Not because of pleiotropy, but just the breakdown of a control system outside of its tested regime.