But is AlphaFold2(x) a (mostly) convex function? More importantly, is the real structure(x) convex?
I can see a potential bias here, in that AlphaFold and inverse AlphaFold might work well for biomolecules because evolution is also a kind of local search, so if it can find a certain solution, AlphaFold will find it, too. But both processes will be blind to a vast design space that might contain extremely useful designs.
Then again, we are biology, so maybe we only care about biomolecules and adjacent synthetic molecules anyway.
Yeah, I agree that there’s probably a bias towards biomolecules right now, but I think that’s relatively easily fixable by using the naive way to predict the amino acid sequence of a structure we want, then actually making that protein, then checking its structure with crystallography and retraining AlphaFold to predict the right structure. If we do this procedure with sequences that differ more and more from biomolecules, we’ll slowly remove that bias from AlphaFold.
By “bias” I didn’t mean biases in the learned model, I meant “the class of proteins whose structures can be predicted by ML algorithms at all is biased towards biomolecules”. What you’re suggesting is still within the local search paradigm, which might not be sufficient for the protein folding problem in general, any more than it is sufficient for 3-SAT in general. No sampling is dense enough if large swaths of the problem space is discontinuous.
But is AlphaFold2(x) a (mostly) convex function? More importantly, is the real structure(x) convex?
I can see a potential bias here, in that AlphaFold and inverse AlphaFold might work well for biomolecules because evolution is also a kind of local search, so if it can find a certain solution, AlphaFold will find it, too. But both processes will be blind to a vast design space that might contain extremely useful designs.
Then again, we are biology, so maybe we only care about biomolecules and adjacent synthetic molecules anyway.
Yeah, I agree that there’s probably a bias towards biomolecules right now, but I think that’s relatively easily fixable by using the naive way to predict the amino acid sequence of a structure we want, then actually making that protein, then checking its structure with crystallography and retraining AlphaFold to predict the right structure. If we do this procedure with sequences that differ more and more from biomolecules, we’ll slowly remove that bias from AlphaFold.
By “bias” I didn’t mean biases in the learned model, I meant “the class of proteins whose structures can be predicted by ML algorithms at all is biased towards biomolecules”. What you’re suggesting is still within the local search paradigm, which might not be sufficient for the protein folding problem in general, any more than it is sufficient for 3-SAT in general. No sampling is dense enough if large swaths of the problem space is discontinuous.