I’d also recommend this article, including the discussion in the comments by researchers in the field.
A crucial distinction I’d emphasize which is almost always lost in popular discussions is that between the toxic amyloid oligomer hypothesis, that aggregates of amyloid beta are the main direct cause of neurodegeneration; and the ATN hypothesis I described in this thread, that amyloid pathology causes tau pathology and tau pathology causes neurodegeneration.
The former is mainly what this research concerns and has been largely discredited in my opinion since approximately 2012; the latter has a mountain of evidence in favor as I’ve described, and that hasn’t really changed now that it’s turned out that one line of evidence for an importantly different hypothesis was fabricated.
I happened to be reading this post today, as Science has just published a story on a fabrication scandal regarding an influential paper on amyloid-β: https://www.science.org/content/article/potential-fabrication-research-images-threatens-key-theory-alzheimers-disease
I was wondering if this scandal changes the picture you described at all?
Not a ton.
I’d also recommend this article, including the discussion in the comments by researchers in the field.
A crucial distinction I’d emphasize which is almost always lost in popular discussions is that between the toxic amyloid oligomer hypothesis, that aggregates of amyloid beta are the main direct cause of neurodegeneration; and the ATN hypothesis I described in this thread, that amyloid pathology causes tau pathology and tau pathology causes neurodegeneration.
The former is mainly what this research concerns and has been largely discredited in my opinion since approximately 2012; the latter has a mountain of evidence in favor as I’ve described, and that hasn’t really changed now that it’s turned out that one line of evidence for an importantly different hypothesis was fabricated.