I had never heard of this condition, but your previously diagnosed ‘Megavitamin-B6 syndrome’ symptoms line up so well with your current symptoms it seems hard to rule out some kind of B vitamin issue.
The other thing that randomly came to mind is gout, which isn’t always super localized to a single joint.
The sudden onset is strange, is there any new medication you took even a few weeks earlier?
There’s also the brute-force test for autoimmune conditions, which is take something like prednisone and see if it immediately resolves the issue. It’s not conclusive because prednisone will also make a sprained ankle or a herniated disc feel pretty good just by nuking all the inflammation. But it’s a data point.
I had never heard of this condition, but your previously diagnosed ‘Megavitamin-B6 syndrome’ symptoms line up so well with your current symptoms it seems hard to rule out some kind of B vitamin issue.
The other thing that randomly came to mind is gout, which isn’t always super localized to a single joint.
The sudden onset is strange, is there any new medication you took even a few weeks earlier?
There’s also the brute-force test for autoimmune conditions, which is take something like prednisone and see if it immediately resolves the issue. It’s not conclusive because prednisone will also make a sprained ankle or a herniated disc feel pretty good just by nuking all the inflammation. But it’s a data point.
My PCP thought the same thing. Fasted b6 was normal and I check everything for b6 now. No new medications before it started.
Gout and autoimmune are good ideas, will follow up on those, thanks!