FWIW, there is other SARS2-specific supporting evidence that immune imprinting may be an issue for vaccine updates. Lately in the UK Health Security Agency weekly vaccine surveillance reports they have begun including this note:
>(iii) recent observations from UK Health Security Agency (UKHSA) surveillance data that N antibody levels appear to be lower in individuals who acquire infection following 2 doses of vaccination.
The UK tracks seropositivity of S and N antibodies. N antibody positivity is used to track the subset of people who were previously infected. This note implies the immune system may not be updating its response when challenged with a new variant of the live virus.
FWIW, there is other SARS2-specific supporting evidence that immune imprinting may be an issue for vaccine updates. Lately in the UK Health Security Agency weekly vaccine surveillance reports they have begun including this note:
>(iii) recent observations from UK Health Security Agency (UKHSA) surveillance data that N antibody levels appear to be lower in individuals who acquire infection following 2 doses of vaccination.
(From page 39 paragraph 3 of https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1036047/Vaccine_surveillance_report_-_week_47.pdf)
The UK tracks seropositivity of S and N antibodies. N antibody positivity is used to track the subset of people who were previously infected. This note implies the immune system may not be updating its response when challenged with a new variant of the live virus.