Thanks, this is very interesting.
One thing I don’t understand: you write that a major problem with viruses is:
As one might expect, the immune system is not a big fan of viruses. So when you deliver DNA for a gene editor with an AAV, the viral proteins often trigger an adaptive immune response. This means that when you next try to deliver a payload with the same AAV, antibodies created during the first dose will bind to and destroy most of them.
Is this a problem for people who expect to only want one genetic modification during their lifetime?
Thanks, this is interesting.
My understanding is that cavities are formed because the very local pH on that particular sub-part of the tooth is below 5.5. IIUC teeth can’t get cancer. Are you imagining Lumina colonies on the gums having this effect there, the Lumina colonies on the teeth affecting the general oral environment (which I think would require more calculation than just comparing to the hyper-local cavity environment) or am I misunderstanding something?