Compounding pharmacies are gray-market. (Buying on “evolutionpeptides.com″ would be black-market.)
Metacelsus
Karma: 904
On Minicircle
No mention of modafinil? It’s quite useful for maintaining productivity on low amounts of sleep.
Semaglutide is the real-deal weight loss drug we have been praying for. It works well for 70%+ of people. Losing and keeping weight off is so difficult that prior to ozempic, it was reasonable advice to preach acceptance or extremely restricted diets. Prior to Semaglutide, I used to assume that most of my friends who wanted to lose weight would fail. Now I assume they will trivially succeed if they get on the drugs. Here is how to get on Semaglutide:
I purchased sema, for myself and others, on this site: https://evolutionpeptides.com/products/semaglutide-10mg?variant=42834747326660. It has been a reliable supplier for me. Reliability can always change, but for now, it’s where I would go.
Start with a dose of 0.25mg. Increase your dose approximately every four weeks. Stay on lower dosages as long as possible. Tolerance can increase rapidly. For example, the official guidelines say to double your dose after each of the first two months of treatment. I would try to increase dosages more slowly.
Gray market semaglutide is sold as a powder. You need to mix it into a solution to inject. Search for reconstitution solution.
You also need needles. Any insulin needle will work fine but some hurt less than others. Here are the ones I use.
To make the solution, I draw 100 units of reconstitution (a ‘full’ vial) solution into the needle. I then squirt the solution into the sema vial and repeat this process again. This means 5mg of semaglutide per 200 units of solution. So, to do a 0.25 starting dose, I would inject 10 units of mixed sema solution into my deltoid. It doesn’t really matter if you inject into fat or muscle.
Semaglutide feels weird in many ways and makes many people nauseous. Fake Dr. Sapphire’s medical advice is to use gray market odansetron to manage nausea. But dramamine is OTC in the USA and most other countries and also works well. Don’t expect insanely rapid weight loss. It’s normal to lose 1-2 pounds a week, which is honestly quite quick!
Injecting anything from the “gray-market” is quite risky, since it may not be sterile. People have died from such things (for example: https://en.wikipedia.org/wiki/New_England_Compounding_Center_meningitis_outbreak)
For biology, JoVE (“Journal of Visual Experiments”) is a very good source of videos like this. https://www.jove.com/ Unfortunately it’s paywalled.
I agree, I think the most likely version of the lab leak scenario does not involve an engineered virus. Personally I would say 60% chance zoonotic, 40% chance lab leak.
A commenter on my Substack got much better results using Claude 3 Opus.
Testing ChatGPT for cell type recognition
Spearman (rank) correlation is often a good alternative for nonlinear relationships.
>heats the water (adenosine diphosphate, ADP) to a closely related, higher-energy form (adenosine triphosphate, ATP), which is steam.
I would say protons are the steam, not the ATP/ADP. The electron transport chain “pressurizes” protons by pumping them, and then the protons flow through the ATP synthase “turbine”.
I think the exact origin of SARS-CoV-2 is a largely irrelevant question.
Given that it’s plausible it could have come either from a wet market or risky biological research, we should shut down both.
(Personally I would say 60% “wet market”, 40% “unintentional lab leak”)
That make sense. If I were going for sarcasm I would have said Kary Mullis.
A Nobel-winning scientist like Gregg Semenza would obviously be the best possible expert
Funny you should say that . . .
https://retractionwatch.com/2023/10/02/nobel-prize-winner-gregg-semenza-tallies-tenth-retraction/
https://www.nature.com/articles/d41586-022-03032-9
Emmett Shear on college-level organic chemistry. His experience was that the class was composed of a mix of science track and premed track students. The science students are there to actually learn and retain the material, so even though it’s a massive amount of compounding facts you have to learn, they do fine. Whereas the premed students are happy to do the work, but are thinking of the class as a structural barrier rather than source of information, so they cram rather than retaining information, and then struggle. So it is a question of motivation. How do we get students, across the board, to be motivated by actually caring about the material?
As a former TA for organic chemistry, I can definitely confirm this.
As a scientist I strongly agree. It seems like there’s been a few steps towards this in recent years, for example with things like the Arc Institute or FROs. Hopefully this model gets the attention of government funders.
>I haven’t heard a “Polack joke” in years and I wouldn’t be surprised if the rising generation is mostly unaware that there ever was such a thing.
On the contrary, I heard one at an ACX meetup in Boston in summer 2023. I was not amused.
>I think it makes sense for some country with a high rate of alcohol flush reaction to legalize using 1-butanol or oxane as a substitute for ethanol in drinks served at bars and restaurants.
The only downside is that butanol tastes pretty awful.
I think it would be useful to examine cases where important patents for Input X expired and prices came down quickly, allowing Input X to be used to produce much more of Product Y.
That is very wrong. Diamond is hard to make with enzymes because they can’t stabilize intermediates for adding carbons to diamond.
As a biochemist, I agree.
Testosterone will land you in more legal trouble than modafinil.