The peptides did not “come from in silico studies”; they came from the antibody profiles of real patients, who really had covid, and really recovered from covid (ideally without having a Bad Time during recovery.) So there’s more than just computational reasons to believe they will be useful.
It’s questionable to complain that radvac did not have a single “research study using any of the peptides in the RADVAC white paper that found they inhibited SARS-CoV-2 infection in cells, let alone animals or humans”, when the pfizer vaccine (which we know works) was designed via the same process a year ago, when we had even less information about effectiveness.
How minor are these quibbles? What’s your overall estimate of the probability of the RADVAC vaccine working and how much did it change upon reading Sarah’s post?
A couple of minor quibbles:
The peptides did not “come from in silico studies”; they came from the antibody profiles of real patients, who really had covid, and really recovered from covid (ideally without having a Bad Time during recovery.) So there’s more than just computational reasons to believe they will be useful.
It’s questionable to complain that radvac did not have a single “research study using any of the peptides in the RADVAC white paper that found they inhibited SARS-CoV-2 infection in cells, let alone animals or humans”, when the pfizer vaccine (which we know works) was designed via the same process a year ago, when we had even less information about effectiveness.
How minor are these quibbles? What’s your overall estimate of the probability of the RADVAC vaccine working and how much did it change upon reading Sarah’s post?